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In 2369, a destroyer intercepted Dr. Richard Galen's shuttlecraft and placed it in their tractor beam. The Yridians were interested in obtaining Galen's research regarding an ancient software program hidden within the DNA of several species, which they wished to sell to the Cardassian Union. The Yridians boarded the shuttle and stole several bits of information from his computer. The USS Enterprise-D intervened and ordered the destroyer to stand down. In response, the Yridians fired at the Enterprise, and was inadvertently destroyed when hit by a single phaser blast from the Enterprise. (TNG: "The Chase")
In 2370, a freighter commanded by Yog rendezvoused with a Klingon Bird-of-Prey controlled by the Duras sisters. The Klingons sold the Yridians several thousand kilograms of magnesite ore stolen from a Pakled mine in the Kalla system. The Enterprise-D, searching for the Duras, arrived in the middle of the transaction. Commander William T. Riker offered one-half gram of Anjoran bio-mimetic gel in exchange for the ore, which he then transported in front of the cloaked vessel and then detonated with the ship's phasers. The magnesite reflected off the Bird-of-Prey, allowing the Enterprise to lock onto the ship with a tractor beam. (TNG: "Firstborn")
In late 2370, Starfleet put together a Yridian convoy as lure for a Maquis attack. The convoy of six ships left Deep Space 9 for the Demilitarized Zone, destined for Cardassian space, carrying a supplies of isomiotic hyposprays, plasma flares and quarantine pods. (TNG: "Preemptive Strike")