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Wise can refer to:
- The Wise Ones, the ancient race that saved the Amerind people
- D. Wise, a Starfleet commander in the 23rd century
- Wise nebula
It may also refer to the following production related staff:
- David Wise, script writer on The Animated Series
- Douglas E. Wise, assistant director on five of the first six movies
- Millicent Wise, wife of Robert Wise and an extra in the first movie
- Ray Wise, an actor who appeared in The Next Generation and Voyager in guest roles
- Robert Wise, director of Star Trek: The Motion Picture
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