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Vitamin deficiencies were a lack of certain necessary vitamins. Humanoids were known to crave foods that were rich in the vitamins and minerals they were deficient in. (VOY: "Elogium")
Vitamin deficiencies could have a negative impact on chromosomes. (TNG: "When The Bough Breaks")
In 2371, The Doctor suggested that Kes might have a nutrient deficiency after the Ocampa voraciously ate soil. (VOY: "Elogium")