In 2155, John Frederick Paxton, leader of the xenophobic group Terra Prime, hijacked the array to further his cause of Human superiority. Using the array to fire on Earth's moon as a demonstration of its power, Paxton threatened to destroy Starfleet Command unless all aliens evacuated the solar system.
When Enterprise NX-01 attempted to stop him, Paxton used the array to fire on Enterprise, critically damaging it. Malcolm Reed noted that the array was only firing at two percent power, and that Paxton could have used the array to vaporize them. Eventually, Captain Archer was successful in leading a team to infiltrate Paxton's base and stop him, but not before Paxton locked in the firing sequence for the array. Fortunately, although they were unable to stop the array from firing, Commander Charles Tucker was able to change the target of the verteron array, which fired harmlessly into the Pacific Ocean. (ENT: "Demons", "Terra Prime")