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In 2268, several volunteers from Gideon were to be deliberately infected with this disease, with the aim of decreasing their population. The microbes used by the Gideons to infect their world were taken from the blood of Captain James T. Kirk, who had nearly died from it prior to his encounter with them. He passed it on to Odona, who suffered for some time before finally being treated by Doctor Leonard McCoy aboard the USS Enterprise. (TOS: "The Mark of Gideon")