(covers information from an alternate timeline)
The Vega colony, located in the Vega planetary system, was a Human colony and an important trade partner of Earth in the early days of Human interstellar exploration. It was one of the earliest colonies established, along with the Alpha Centauri and Terra Nova colonies. Vega colony was, for many decades, located on the frontier of known space.
In 2152, Admiral Forrest speculated that an escape pod-like vessel, found by Enterprise NX-01, might have been launched by Vega colony. However, the small vessel was later discovered to be a timeship from the 31st century. (ENT: "Future Tense")
In 2254, the USS Enterprise planned to make use of the medical facilities at the Vega colony to take care of the crew injured on Rigel VII and replace the personnel who needed hospitalization. (TOS: "The Cage", "The Menagerie, Part I")
The location of Vega was seen on a Federation star chart displayed in astrometrics on the USS Voyager in 2376. The system was shown in relation to Pollux IV, Jouret IV, Rigel, and Organia. (VOY: "Child's Play")
Prior to 2151, Earth ships had been operating within 90 light years of the Sol system. In that year, the Enterprise became the first ship to travel further than this distance. (ENT: "Two Days and Two Nights")
The Vega colony (or Vega IX) was located in the Alpha Quadrant. In the mid-22nd century, this important trading world was located in non-aligned space. As a destination on the Earth trade routes, it traded with Draylax and Earth in the mid-22nd century. In 2378, the Vega colony was located in or near Federation space. The colony was a destination on the major space lanes. Vega colony was a Federation member. (pgs. 36, 44, "United Federation of Planets I")
In Star Trek Online, the Vega colony was the site of the Borg reemergence in the galaxy during the year 2409, Starfleet attempted to evacuate the Vega colony while engaging the Borg fleet in orbit. This location served as the tutorial for the game as the player attempted to defend the evacuees and then repel the invasion force.