The USS Syracuse was a 24th century Federation starship operated by Starfleet.

After serving on the USS Philadelphia, Alfonse Pacelli was assigned to the Syracuse on stardate 40276.2. This ship was named in his personnel file. (TNG: "Eye of the Beholder", okudagram)

This starship was only mentioned in writing.
The name of this ship was in honor of either the city in North America or after the Italian city of Siracusa on Sicily.