The USS Prokofiev was a 24th century Federation starship operated by Starfleet.

The Prokofiev was dispatched to the border of the Cardassian Demilitarized Zone in late 2370, following the arrest of Starfleet member Miles O'Brien. The USS Enterprise-D and the USS Valdemar were also ordered to patrol the border of the DMZ. (DS9: "Tribunal")

The Star Trek Encyclopedia (4th ed., vol. 2, p. 333) classified the Prokofiev as an Andromeda-class starship, with registry number NCC-68814.
The Star Trek Encyclopedia (4th ed., vol. 2, p. 183) stated this shp was "named for the 20th century Russian composer of Peter and the Wolf."
According to her personnel file in the non-canon video game Star Trek: Starship Creator, Ensign Melora Pazlar was assigned to the stellar cartography department on the Prokofiev following the events of "Melora".

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