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Lieutenant Jadzia Dax takes a Trill initiate Arjin on a trip through the wormhole and back in the Mekong. During the flight, the runabout ran through a subspace interphase pocket. The runabout's starboard nacelle snagged a piece of what was first referred to as "subspace seaweed" but was later discovered to be a protouniverse. (DS9: "Playing God")
In late-2370, the Mekong was fitted with additional photon torpedoes and accompanied the USS Odyssey into the Gamma Quadrant in an attempt to rescue Commander Benjamin Sisko, then a prisoner of the Dominion. (DS9: "The Jem'Hadar")
In 2371, returning from consultations at a Bajoran colony, Major Kira Nerys and Odo detected a Maquis attack in progress. They pursued the attacking ship in the Mekong but due to prevailing conditions, the pursuit took them down to the surface of a moon with an atmosphere that was impenetrable to the runabout's sensors. (DS9: "Heart of Stone")
Later in the same year, Odo and Elim Garak took the Mekong to the Unefra system in search of Enabran Tain. They located him, but were subsequently captured by the warbird commanded by Lovok and Tain, and sequestered in the warbird's shuttlebay on "E" Deck, Section 25. The runabout was then carried into the Gamma Quadrant. The Mekong was abandoned after Odo and Garak, attempting to escape the Battle of the Omarion Nebula, were beamed aboard the USS Defiant. (DS9: "The Die is Cast") The ship's fate is not known, although it was presumably destroyed as a new runabout, USS Rubicon, had been assigned to the station by the end of 2371, and the Mekong was never mentioned again. (DS9: "Family Business")
|USS Gander • USS Ganges • USS Mekong • USS Orinoco • USS Rio Grande • USS Rubicon • USS Shenandoah • USS Volga • USS Yangtzee Kiang • USS Yukon • NCC-73918 • Unnamed|