The USS Hispaniola was a 24th century Federation starship operated by Starfleet.

In 2370, the captain of this ship was J. Gump. The starship's point of departure was the Sol system. The starship arrived at Deep Space 9 on stardate 47553.2. The USS Hispaniola was named on the space station's arrival roster. (DS9: "Whispers" production art)

This starship was only mentioned in writing.