Prior to the ship's disappearance in 2370, the Hera was under the command of Captain Silva La Forge. This starship had a crew of over three hundred that consisted mainly of Vulcans. The Hera's warp coils used trionic initiators.
In late 2369, seven months before the ship's disappearance, Silva La Forge assumed command of the starship. To celebrate, Captain La Forge hosted a party for her crew.
The following year, three weeks before her disappearance, the Hera received several new transfers including a chief engineer who liked to "juice" the engines. A week later, the Hera was in the same sector as the USS Enterprise-D.
Ten days before the ship's disappearance, the Hera traveled close to the planet Marijne VII before arriving at Deep Space 3. A day later, after receiving her orders, the ship left on a courier run, and was in communication with the space station for five days. On the sixth day, the station failed to establish a connection with the ship, and three days later, the Hera was declared missing. The ship's last reported position was over 300 light years from Marijne VII.
A massive search mounted by the USS Excelsior and the USS Noble failed to discover any trace of the ship. The ship was believed lost and a memorial service was later held for the crew on Vulcan. (TNG: "Interface")