The USS Fleming was a 24th century Federation starship operated by Starfleet. This medical transport was constructed of such materials as duranium and polycomposites.

In 2370, the Fleming was transporting a cargo of bio-mimetic gel through the Hekaras Corridor when it was disabled by Hekaran scientists who were attempting to gain the attention of Starfleet.

The Fleming was later caught in a subspace rupture that had formed in the Corridor, where it had to be abandoned. Its crew was rescued by the USS Enterprise-D. (TNG: "Force of Nature")

The Star Trek Encyclopedia (4th ed., vol. 1, p. 275) classified this vessel as a Wambundu-class starship, with the registry number NCC-20316. The authors of this reference work stated the starship was "named for Sir Alexander Fleming, the British bacteriologist who discovered penicillin."

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