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The Sovereign-class USS Enterprise-E has had crewmembers belonging to a variety of races and hailing from many planets. Over time, they have included Humans, Vulcans, a Betazoid, Bolians, Trill and an android. Many of the crew transferred from their assignments on the USS Enterprise-D.
- For unnamed personnel, see Unnamed USS Enterprise (NCC-1701-E) personnel.
Worf was shown working in tandem with the crew of the Enterprise-E, but was never apparently assigned to the crew.