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This page contains information regarding Star Trek: Short Treks, and thus may contain spoilers.

The USS De Milo was a 23rd century Hoover-class Federation starship operated by Starfleet.

At some point, a number of bounty hunters started to contact the De Milo with what on first glance appeared to be Harcourt Fenton Mudd, an individual wanted by the Federation. However, they were in fact android duplicates.

Within a week, the De Milo had collected at least eight androids, some of which had detached limbs, and one reduced to banging his head against a cargo container. They were placed in a cargo hold aboard the ship.

Among the bounty hunters taken in by the androids were a Tellarite named Tevrin Krit, who was informed of his mistake after his vessel, D-756, rendezvoused with the De Milo. (ST: "The Escape Artist")

The interiors of the De Milo were simple re-uses of the USS Discovery sets.
It is unclear when these events happened, but Mudd being on the hook for "penetrating a space whale" suggests it takes place after "Magic to Make the Sanest Man Go Mad", meaning after 2256.