In 2377, Captain Peterson was the commanding officer of this ship. In that year, it was diverted by Admiral Owen Paris to intercept a Ferengi Marauder that was interfering with Project Pathfinder's communications with the USS Voyager.
At the time, the Marauder had created a geodesic fold, which it was attempting to lure Voyager through; an event that would have subsequently killed all aboard. Reginald Barclay suggested using the Carolina to close the fold, however, the ship was not equipped to perform such a task. (VOY: "Inside Man")