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The USS Cairo was a 24th century Federation Excelsior-class starship operated by Starfleet.

In 2369, it was under the command of Captain Edward Jellico, who was temporarily transferred to command the USS Enterprise-D for a special diplomatic mission to the Cardassian border. (TNG: "Chain of Command, Part I") The Cairo was deployed to defend the Federation system Minos Korva when it was threatened by a potential Cardassian attack. Following the peaceful conclusion of the crisis, Captain Jellico returned to his command on the Cairo. (TNG: "Chain of Command, Part II")

During the Dominion War, the Cairo was commanded by Captain Leslie Wong, and assigned to patrol the Romulan Neutral Zone in 2374. The ship was believed to have been ambushed and destroyed by Dominion forces who had crossed Romulan space to attack the Cairo. (DS9: "In the Pale Moonlight")

The Cairo was named after the Egyptian capital.(citation needededit)
The Star Trek Encyclopedia (4th ed., vol. 2, p. 327) listed the Cairo with the registry NCC-42136. In the Star Trek Encyclopedia (3rd ed., p. 471), the Cairo was identified as the unnamed Excelsior class starship in "Preemptive Strike". For the fourth edition, this was changed to where the ship in "Preemptive Strike" was not identified as the Cairo.

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