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When Seven of Nine began exhibiting multiple personalities in 2375 because of a dysfunctional Borg vinculum infected with a virus, The Doctor found that in this case, the "Typhoid Mary" was Species 6339 that carried a synthetic pathogen within their bodies; once they were assimilated by the Borg, the virus spread to the vinculum, which in turn caused havoc, leading to dysfunction and eventually the destruction of the Borg cube's drones. (VOY: "Infinite Regress")