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In 2370, Grand Nagus Zek assigned Quark to open trade negotiations with the Dosi to purchase 10,000 vats of tulaberry wine, in the first Ferengi business venture in the Gamma Quadrant. However, he later sabotaged the negotiations by changing the order to 100,000 vats, well beyond what the Dosi could produce. Zek's true goal was to do business with the Dominion, and his plan succeeded when the Dosi businesswoman Zyree referred Quark to the Karemma. (DS9: "Rules of Acquisition")
The Ferengi did establish a tulaberry wine trade with the Karemma that year, and, possibly as a reward for his service, Quark gained ownership of several tulaberry wine franchises. (DS9: "The Search, Part I", "Family Business")