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A sedative or a tranquilizer was a drug used to calm down a patient or to induce sleep. Sedatives were often administered with a hypospray in a dosage of usually not more than several ccs.

According to the Star Fleet Medical Reference Manual, (p. 38) the standard tranquilizer used by the Federation was diphenylmethane compound.

In 2153, Doctor Phlox tried to give the Borg-assimilated Tarkalean male a sedative but was thrown over the bed after the Tarkalean injected him nanoprobes by using his assimilation tubules. (ENT: "Regeneration")

Aldebaran mud leeches could be used to treat insomnia as their secretions acted as a natural sedative. (ENT: "Anomaly")

In 2155 in the mirror universe, Doctor Phlox used a sedative on a Tholian to keep it from making a transmission. When it stopped working, Captain Maximilian Forrest ordered him to kill it. (ENT: "In a Mirror, Darkly")

Leonard McCoy gave James T. Kirk a mild sedative to alleviate the effects of the Melvaran mud flea vaccine: Kirk fell unconscious, which McCoy found "unbelievable". (Star Trek)

Captain Picard's aunt Adele's recipe for a warm milk toddy was working perfectly as a natural sedative, as the heat activated amino acids in the lactose and it also tasted delicious. (TNG: "Schisms")

Constable Odo told the Rakhari criminal Croden he would sedate him if he would not be quiet during their trip to Rakhar. (DS9: "Vortex")

Makara herbs could act as an antidote to sedatives. While taking these herbs during her pregnancy, Major Kira Nerys was able to overpower Silaran Prin by pretending the sedatives he gave her worked. (DS9: "The Darkness and the Light")

In 2373, when Neelix was nervous about serving on an away mission to a Nezu colony planet, The Doctor picked up on his apprehension and suggested that he might need a tranquilizer. (VOY: "Rise")

That same year, when Ensign Harry Kim was attacked by a member of Species 8472, The Doctor tried giving him a sedative, but his body immediately rejected it, forcing Kim to endure extreme pain as his body was in essence "being eaten alive." (VOY: "Scorpion")

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