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In 2154, the Enterprise NX-01 received word that the Ticonderoga was missing approximately six hours from Andoria. When Enterprise arrived at the last known coordinates of the Ticonderoga, it was discovered that it had been destroyed by a Romulan drone ship. All that remained of the Ticonderoga was hull fragments, nacelle casings and several Human bodies. (ENT: "The Aenar")