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The Tibor Nebula was an interstellar gas cloud located in Federation space.

In 2374, Starfleet planned for the Seventh Fleet to cut off a supply line the Dominion was trying to establish through Betazoid space into the Argolis Cluster (with the presumed purpose of the Jem'Hadar attacking Vulcan) with a battle near the nebula. (DS9: "The Reckoning")

This nebula was only mentioned in dialogue.
According to Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), the Tibor Nebula was located in the Alpha Quadrant.