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The thyroid was a large gland found in a humanoid's endocrine system, which regulated hormones in the body.

The disease known as hyperthyroidism came as a result of an "overactive thyroid." (TOS: "This Side of Paradise"; DS9: "The Abandoned")

In the Denobulan language, the phrase for the thyroid gland is "Ya-sah mai gaa-am". Phlox mentioned this while testing Hoshi Sato's Denobulan while she was recovering after being injured by a Romulan mine in 2152. (deleted scene, ENT: "Minefield")

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