(covers information from several alternate timelines)
In 2152, making an unusual move, the Tholians traveled far beyond their territory, as they attempted to possess a 31st century time-travel pod discovered by the Earth starship Enterprise. Four Tholian starships intercepted and disabled the Vulcan cruiser Tal'Kir while it waited to rendezvous with Enterprise. They also attacked and defeated a fleet of Suliban vessels that were in pursuit of the arriving Earth ship. They then successfully removed the pod from Enterprise's possession, only to have the pod return to its proper timeline moments later. (ENT: "Future Tense")
In the mirror universe, numerous Tholian starships were encountered by the ISS Enterprise in 2155. A single vessel of this class was no match for an Template:ShipClass vessel, though several of these vessels were capable of destroying such a vessel, particularly when employing a Tholian web.
These vessels later discovered Enterprise's illegal presence in the Vintaak system, attempting to steal the USS Defiant. Several of these ships encased Enterprise with a web, then proceeded to destroy it with weapons fire. These vessels later attempted to block the Defiant to prevent its theft, only to be destroyed. (ENT: "In a Mirror, Darkly", "In a Mirror, Darkly, Part II")
Tholian vessels were of a characteristic conical shape, and their small size made these vessels highly agile. This class was outfitted with formidable weaponry, including a type of energy-dampening weapon which they used against Enterprise to render it almost completely powerless. The interiors of these vessels were kept at temperatures exceeding 200 °C. (ENT: "Future Tense", "In a Mirror, Darkly")