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The Great Experiment was a nickname that was used to describe the first extrasolar colonization of Terra Nova during the 21st century. (ENT: "Terra Nova")

By the 23rd century, the nickname was applied to the USS Excelsior, the prototype of the successful Excelsior-class. She was noted as such for having been outfitted with transwarp drive. (Star Trek III: The Search for Spock)