Teratogenic coolant was a type of coolant used for the subspace warp field propulsion system on mid-24th century Federation starships. This coolant prevented the engines from overheating by removing excess heat. Engineers were taught safety measures in technical manuals, for example, Teratogenic Coolant Safety Protocol, when working around and with this gas.

This coolant was used aboard the USS Enterprise-D. (TNG: "Booby Trap", okudagram)