Talos II was the second planet in the Talosian system, which was located in the Talos star group.

In 2254, the position and orbital path of Talos II in an inner system map was displayed on the bridge of the USS Enterprise. The planet was located at 1.8 astronomical units from the binary stars Talos A and Talos B. (TOS: "The Cage", "The Menagerie, Part I", production art)

According to the Star Trek: Star Charts (pp. 37 & 40), Talos II was classified as a H-class planet. This planet was located in the Alpha Quadrant.

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