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(covers information from several alternate timelines)
Sweat was a byproduct of vigorous exercise or exertion. In 2266, Doctor Leonard McCoy encouraged a reclining James T. Kirk to keep pedaling until he worked up a little sweat, saying it would do him good. (TOS: "The Corbomite Maneuver")
Concerned that Worf was taking an upcoming game of Parrises squares too seriously, Riker told him it was just a game, saying "You work up a sweat, you have a few laughs, and you make new friends." (TNG: "11001001")
An upset Jadzia Dax suggested that a cold-footed Worf go back to sweating and bleeding in the holosuite with his friends and when he was finished, Benjamin Sisko could perform their wedding ceremony in his office. (DS9: "You Are Cordially Invited")
Odo's assessment of Kurn's prowess as a Klingon warrior was that he could have disarmed a Boslic captain without breaking a sweat. (DS9: "Sons of Mogh") Julian Bashir played a Vulcan in the racquetball finals at Starfleet Medical Academy in his senior year. He remarked on the Vulcan's stamina, saying he didn't think the man had even broken a sweat. (DS9: "Rivals")
Sweat could also be produced due to prolonged exposure to heat from an external source. In 2373, Pascal Fullerton described himself as "a middle-aged ponderous academic, sweating under the hot Risian suns" (DS9: "Let He Who Is Without Sin...")
Sweating as a medical symptom Edit
While under the influence of polywater intoxication, Hikaru Sulu remarked that he was "sweating like a bridegroom," though he wasn't sure whether it was caused by Psi 2000 or Tormolen's death. Riley also remarked that he was sweating, too. Later, McCoy discovered that perspiration was the vector responsible for transmitting the illness. (TOS: "The Naked Time")
Increased perspiration rate among males present in the briefing room was one of the symptoms reported by the USS Enterprise's computer when Kirk asked for sensor probe readings. This indicated, much to the embarrassment of Kirk and other men present at the time, that they were physically attracted to Mudd's women. (TOS: "Mudd's Women")