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Stress was a medical condition which appeared on individuals who suffered from exhaustion and too much work.

T'Pol mentioned that Phlox was under extraordinary physical stress during his assimilation process of the Borg what would explain the voices he heared during this time. (ENT: "Regeneration")

In 2153, Tucker told Captain Jonathan Archer that Chef was worried about the crew. They were skipping meals and he suggested it would be either too much work or the Xindi mission. (ENT: "Impulse")

According to Doctor Leonard McCoy's log, Kirk showed signs of stress and fatigue just prior to his 2267 visit to the Shore Leave Planet. (TOS: "Shore Leave")

While attempting to locate an older Arne Darvin on the USS Enterprise in 2268, Doctor Julian Bashir pretended to be doing a study on work-related stress, using "Ensign" Miles O'Brien as his test subject. (DS9: "Trials and Tribble-ations")

By 2371, Starfleet Academy had a stress reaction test for its cadets. (DS9: "Facets")

A therapy for stress-related muscle tension was the osteopathic pressure therapy. (VOY: "Scientific Method")

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