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Starbase 343 was a Federation starbase administered by Starfleet.

In 2366, the USS Enterprise-D was diverted to the starbase to transport urgently needed medical supplies to the Alpha Leonis system, postponing its rendezvous with the USS Goddard. Several Enterprise crewmembers took extended shore leave here during this transport, as it was expected to be a quiet mission. (TNG: "The Vengeance Factor")

Starbase 343 was located in the Beta Quadrant. (Star Trek: Star Charts, page 62)

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