Starbase 220 was a Federation starbase administered by Starfleet.

The USS Enterprise-D was supposed to bring the USS Brattain to Starbase 220, when this ship was stranded in a Tyken's Rift. After the Enterprise had freed itself from the rift, the ship set a course for this starbase. (TNG: "Night Terrors")

This starbase was only mentioned in dialogue.

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