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Starbase 22 was a Federation starbase administered by Starfleet in the 2250s.

During the first Federation-Klingon War, on stardate 4851.5, a cloaked Klingon raider, on a suicide mission, tailed the USS Saratoga into spacedock at this base, where it ignited its antimatter supply. The subsequent explosion destroyed most of the ships docked there. This assault, along with two other similar assaults at Starbase 12 and Starbase 19, resulted in the destruction of one-third of Starfleet's ships. (DIS: "The War Without, The War Within")

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