Starbase 157 was a Federation starbase administrated by Starfleet, in the Beta Quadrant.

The starbase was operational by at least 2256. (DIS: "Choose Your Pain")

In 2256, this starbase's location was labeled on the star chart "Alpha/Beta Quadrant Overview" in the ready room aboard the USS Discovery. (DIS: "Magic to Make the Sanest Man Go Mad")

In 2366, this base picked up the final distress call from the transport Lalo. The Lalo reported encountering an unknown, cube-shaped vessel, which was later encountered and identified by the USS Enterprise-D as a Borg ship. (TNG: "The Best of Both Worlds")

According to, this starbase was located close to the Mempa sector.
According to the Star Trek: Destiny novel Gods of Night, Starbase 157 was destroyed by the Borg in 2381.
Taking place in 2409, the computer game Star Trek Online depicted Starbase 157 as being located near the Klingon border and hosting a large ship yard facility.

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