Starbase 157 was a Federation starbase administrated by Starfleet.

In 2366, this base picked up the final distress call from the transport Lalo. The Lalo reported encountering an unknown, cube-shaped vessel, which was later encountered and identified by the USS Enterprise-D as a Borg ship. (TNG: "The Best of Both Worlds")

According to the Star Trek: Destiny novel Gods of Night, Starbase 157 was destroyed by the Borg in 2381.
Taking place in 2409, the computer game Star Trek Online depicted Starbase 157 as being located near the Klingon border and hosting a large ship yard facility.
According to the Star Trek: Star Charts (p. 62) and the Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), Starbase 157 was located in the Beta Quadrant.

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