Starbase 10 was a Federation starbase that was administered by Starfleet. The base was located near the planet Deneva. A direct course from Gamma Hydra to this base would pass through the Romulan Neutral Zone.
In 2267, the USS Enterprise traveled to this base following its mission to Deneva. Later that year, Commodore George Stocker was assigned command of the base and was transported there by the Enterprise. (TOS: "Operation -- Annihilate!", "The Deadly Years"; VOY: "Tinker Tenor Doctor Spy")