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(written from a Production point of view)
The first two novels detail Khan's creation, childhood, rise to power, fall from power, and reasons for leaving Earth on the DY-100 class sleeper ship SS Botany Bay in 1996, which was later found by the crew of the USS Enterprise in 2267.
The third novel takes place between the TOS episode "Space Seed" and Star Trek II: The Wrath of Khan, and details Khan's life while he was marooned on Ceti Alpha V. It also gives a plausible explanation for how Khan knew Chekov.