The Spanish Inquisition was an inquisition that occurred in Spain.

In 2286, Doctor McCoy's view on primitive 20th century Earth medicine, including the use of image therapy and radical chemotherapy as the only means of an ailing patient's survival, was less than positive. After hearing that two doctors at Mercy Hospital had an argument over the issue, McCoy stated that the whole scenario "sounded like the goddamn Spanish Inquisition" to him. (Star Trek IV: The Voyage Home)

In 2369, Q told Vash that he believed the Spanish Inquisition to be, along with the Crusades and Watergate, among the most interesting events to happen on Earth. (DS9: "Q-Less")

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