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Space sickness was often brought on by turbulence on a ship, or inertial dampeners being out of alignment, and was especially strong if a ship lacked artificial gravity. In many ways, space sickness was the deep space equivalent to sea sickness. Just as an experienced sailor was said to have "sea legs", experienced space travelers were said to have "space legs". (ENT: "Sleeping Dogs", "The Xindi", TOS: "The Lights of Zetar") Nonetheless, most space travelers experienced space sickness from time to time. Space sickness could be treated by inaprovaline. (VOY: "Relativity")
In 2374, B'Elanna Torres, while floating in space with Tom Paris, told him that the experience of being in space with EV suits was nothing like the simulations at Starfleet Academy and it made her feel a little sick to her stomach. (VOY: "Day of Honor")
Doctor Julian Bashir handed Ezri Dax twenty milligrams of a medicine in a hypospray when she boarded the transport to New Sydney and told her it should help her with her space sickness. (DS9: "Prodigal Daughter")