Sector 52 was a region of space. A section of the Romulan Neutral Zone was located in Sector 052/32.

In 2364, the Federation starships USS Tranquillity Base, USS Max Plank, and USS Non Sequitur and the starbase Starbase Trailer Twenty-Nine were ordered by Starfleet Command to increase sensor drone surveillance of this sector. This sector was mentioned in mission orders. (TNG: "Conspiracy", okudagrams)

This sector was only mentioned in writing.