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(covers information from several alternate timelines)
In 2364, communication with Federation starbases in this sector ceased as of stardate 41903.2. The identity of the assailant that had destroyed the bases was unknown at the time. (TNG: "The Neutral Zone") It was later on determined that the Borg were responsible for the attack. (TNG: "Q Who")
In the alternate 2259, this sector was labeled on a map of the Alpha Quadrant. This map was in a collection of graphics and video media that were seen on a powerwall in the offices of Admirals Christopher Pike and Alexander Marcus at Starfleet Headquarters. (Star Trek Into Darkness)