(covers information from several alternate timelines)
This page contains information regarding new Star Trek material, and thus may contain spoilers.
Scotch was one of the many alcoholic beverages enjoyed by Zefram Cochrane. In April 2063, the night before his historic warp flight abroad the Phoenix, Cochrane, who along with Deanna Troi was already drunk on multiple shots of tequila, poured a glass for Troi and himself, telling her it was the "good stuff" - though after seeing her less-than-thrilled reaction (a spectacle which Will Riker, having just discovered her in the bar, very much enjoyed witnessing), he decided it wasn't so good after all and threw the bottle on the ground, almost hitting Riker. The following evening, after the Vulcan survey ship T'Plana-Hath followed the Phoenix back to Earth and made First Contact, Cochrane served Scotch to the visitors, making the beverage the first example of Human cuisine consumed by an (acknowledged) alien race. (Star Trek: First Contact)
In 2153, Arctic Archaeology Team scientist Drake made a bet with Commander Williams about the discovery of a crashed vessel, and won a bottle of scotch. Unfortunately, he was assimilated by the Borg before he could claim his prize. (ENT: "Regeneration")
Later that year, shortly after Enterprise NX-01 departed from Earth on a heading to Vulcan, Captain Jonathan Archer and Commander Charles Tucker III shared a bottle of Scotch in the vessel's mess hall. At one point, they toasted a round of the drink to Henry Archer. (ENT: "The Expanse")
Montgomery Scott had a refined taste for Scotch. Chekov once claimed that Scotch "was inwented [sic] by a little old lady from Leningrad," when Scott attested to Scotch's superiority over vodka. In the alternate reality, Chekov made the same claim to an alien woman at Kirk's birthday party in 2263. Scott's palate was sensitive enough to tell the synthehol variety from the real thing. (TOS: "The Trouble with Tribbles"; Star Trek Beyond; TNG: "Relics")
In 2374, Worf and Miles O'Brien wagered a bottle of bloodwine against a bottle of Scotch whisky if Jadzia Dax beat Quark in a game of tongo. Quark was triumphant and O'Brien told Worf that he would like "Single malt, preferably something from the Highlands." (DS9: "Change of Heart")