Science Station Delta-05 was a distant Federation outpost in sector 3-0. This outpost, located on a planet, was located on the edge of the Romulan Neutral Zone. It was one of nine outposts located in its sector.

In 2364, Science Station Delta-05 was the first stop of the USS Enterprise-D's tour of the sector. The crew of the Enterprise-D determined that the outpost had been obliterated by an unknown assailant. (TNG: "The Neutral Zone")

In 2365, the assailant was later identified as the Borg. (TNG: "Q Who")

This outpost was only mentioned in dialogue.
According to Star Trek: Star Charts (p. 66, "United Federation of Planets II") and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), Science Station D-5 was located in the Beta Quadrant.