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Schizophrenia was a serious mental condition. It was often incorrectly generalized as having "split personalities"; although one type of the ailment caused this, there were several different types, some causing, for example, a prolonged catatonic state. (TOS: "Dagger of the Mind")

By the 2020s, there were several effective treatments for schizophrenia that could cure the condition. People with schizophrenia were placed in the Sanctuary Districts and classed as "Dims". (DS9: "Past Tense, Part I")

In 2266, Dr. Leonard McCoy discounted schizophrenia as the cause of Simon Van Gelder's insanity. (TOS: "Dagger of the Mind")

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