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The Sakharov was a Federation type 7 shuttlecraft that was in service with Starfleet in the mid-24th century, attached to the USS Enterprise-D. It was shuttlecraft 01.

In 2365, Dr. Katherine Pulaski had Lieutenant Commander Data pilot the Sakharov to a position away from the Enterprise-D so she could transport aboard one of the affected children from the Darwin Genetic Research Station. There was concern that the children were carrying an unknown pathogen, and Pulaski wanted to examine one of them outside of styrolite stasis. The Sakharov served as a way to maintain a quarantine.

While aboard the shuttle, Pulaski learned that the children were in fact the cause of the hyperaging observed on the station and the USS Lantree and became infected herself. Data later landed the Sakharov on Gagarin IV, but the shuttle was retrieved once a method to reverse the hyperaging was devised. (TNG: "Unnatural Selection")

Later that year, the Sakharov transported Master Strategist Sirna Kolrami to the Enterprise where he would be meditator and observer for Operation Lovely Angel, a planned Starfleet battle simulation. (TNG: "Peak Performance")

In early 2366, the Sakharov was shown as available for use in the Main Bay on the shuttlebay operations LCARS display. (TNG: "Evolution", okudagram)

Several months later, Q stole the Sakharov from the Enterprise. He had been turned Human as punishment by the Q Continuum and was promptly attacked by several species he had once antagonized, including the Calamarain. The Enterprise was able to ward off the Calamarain, but was unable to assist the civilization on Bre'el IV with its shields raised.

Q piloted the shuttlecraft and lured the Calamarain away from the Enterprise. This selfless act proved to Q2 that Q had learned his lesson, and Q's powers were restored. The shuttle vanished, but was probably returned to the Enterprise shuttlebay. (TNG: "Deja Q")

In 2369, the Sakharov was used to plant mines on the hulls of Cardassian warships hiding in the McAllister C-5 Nebula. The mission was flown by Commanders Riker and La Forge. (TNG: "Chain of Command, Part II")

This ship was used in the progam Picard Delta One, which was a program created by Captain Jean-Luc Picard in 2369 to fool the sentient hologram James Moriarty. Moriarty believed he and the Countess Regina Barthalomew were on board the real Enterprise-D and were given a real shuttlecraft to explore the cosmos together. In reality, their programs were confined to a small holographic data cube which simulated an entire universe for the two to explore. (TNG: "Ship in a Bottle")

According to the Star Trek Encyclopedia (3rd ed., p. 226), a type 6 shuttlecraft named Justman was filmed on the stage; however, for the launching and flight of the shuttle, stock footage of the Sakharov was used.
According to Star Trek Encyclopedia (3rd ed., p. 426), the Sakharov was named for "Russian nuclear scientist and peace advocate Andre Sakharov (1921-1989)."

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