Rudellian plague was an infectious disease that afflicted Cardassians.

The Cardassian colony on Pentath III suffered an outbreak of Rudellian plague in 2372, due to a decline in public health caused by the Klingon-Cardassian War. Several medical relief convoys were sent in response to the epidemic, each escorted by a Federation starship. (DS9: "Rules of Engagement")

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According to Star Trek: Star Charts (p. 46) and Stellar Cartography: The Starfleet Reference Library ("Federation Historical Highlights, 2161-2385"), there was a star system named Rudellia, which might possibly be the system of origin for this plague, in the Alpha Quadrant. The system's primary was a G-class star.

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