Rudellian brain fever was an infectious disease that could cause mental problems.

In 2373, Miles O'Brien at first speculated there had been an outbreak of Rudellian brain fever on Bajor, when his wife told him she wasn't Keiko; in fact, however, Keiko's body had been taken over by a Pah-wraith. (DS9: "The Assignment")

According to the Star Trek: Star Charts, on page 46, the Rudellian brain fever originated from the Rudellia system. This system's primary was a yellow dwarf. The system was located in the Alpha Quadrant.
According to the script, Rudellian was pronounced as "roo-DAY-lee-un". [1]

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