A road was a thoroughfare built to allow for ease of travel. A public road was generally called a street. There were also many other types of roads, such as, alleys, avenues, boulevards, drives, freeways, highways, interstates, off-ramps, railroads and tubes.
In 2256, when Michael Burnham asks Captain Gabriel Lorca how a starship could travel on spores, he tells her to imagine a microscopic web that spans the entire cosmos that functions as an intergalactic ecosystem with infinite roads leading everywhere. (DIS: "Context Is for Kings")
In 2376, on the holodeck on Voyager, when Michael Sullivan met Kathryn Janeway at a pub in Fair Haven, Kathryn told him she was just passing through town, and he asked her how long she had been on the road. (VOY: "Fair Haven")
Chakotay once recited to Captain Kathryn Janeway a line from Dante's Inferno, and how he agreed with it, telling her that if you always see the road ahead of you, it is not always worth the trip. (VOY: "Shattered")