A resonance frequency scan was a type of scientific scan used to determine resonance frequency. It was the first scan performed in a Federation standard plasma analysis.

In 2369, the crew of the USS Yosemite ran a resonance frequency scan on a sample of plasma from a plasma streamer in the Igo sector. However, they were unaware that the sample contained quasi-energy microbes, which reacted to the scan by shattering the container. The microbes then infected the Yosemite crew, threatening their lives. (TNG: "Realm of Fear")