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Relay Station 452 was a Federation communication relay station that was in service with Starfleet in the mid-24th century.

In 2369, this station was named on the chart Sector Ipai Relay Log - Relay Message Flow 1293 in Relay Station 47 Ops. The USS Merrimac sent a message to this station. (TNG: "Aquiel", production art)

This station was only mentioned in writing.