Regulus was an inhabited planet in the Alpha Leonis system, in the Beta Quadrant.

In 2254, Captain Christopher Pike, in a conversation with CMO Boyce, spoke of retiring from Starfleet service and going into business on this planet. (TOS: "The Cage", "The Menagerie, Part I"; DIS: "Magic to Make the Sanest Man Go Mad")

Regulus, the primary of the Alpha Leonis system, was located in the Beta Quadrant on a star chart seen in the Star Trek: Discovery episode "Magic to Make the Sanest Man Go Mad"}.

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