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While raising the mimetic simbiot Sim, Doctor Phlox explained in a letter to Dr. Lucas how he was at a loss to understand how Human adults could endure the REM cycle interruptions that accompany the teething stage of a Human infant. (ENT: "Similitude")
In 2367, the Tyken's Rift being tried to communicate with the crews of USS Brattain and the USS Enterprise-D during their sleep, and was responsible for the loss of the REM sleep, and eventual madness and death of the Brattain crew. (TNG: "Night Terrors") When Commander William T. Riker wasn't able to sleep properly, due to tampering by solanogen-based lifeforms, Doctor Crusher first assumed that his problems were caused by a lack of REM sleep. (TNG: "Schisms")
In 2377, Harry Kim asked Seven of Nine if the information she discovered about Unimatrix Zero was part of a dream. The Doctor disputed that, claiming she never reached REM sleep. (VOY: "Unimatrix Zero")