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In 2268, when Captain Kirk was showing signs of increased tension and emotional stress, he repeatedly resisted Doctor McCoy's attempts to run a psychological profile on him. Unbeknownst to McCoy, Kirk was working under Federation orders to steal a Romulan cloaking device. (TOS: "The Enterprise Incident")
In 2364, the "psych test", a portion of the Starfleet Academy entrance exam, used information from applicants' psychological profiles to construct a situation involving the applicant's greatest fears. (TNG: "Coming of Age")
While visiting Doctor Julian Bashir on Deep Space 9, Doctor Lewis Zimmerman started building a complete psychological profile of Bashir for use in his Long-term Medical Holographic program. Building a complete profile involved interviewing Bashir's closest friends and family. (DS9: "Doctor Bashir, I Presume")